Curaxins: Anticancer Compounds That Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT

• DOI: 10.1126/scitranslmed.3002530
• Publication Date: 2011-08-10T20:20:32Z
• Authors: Alexander V. Gasp...; Catherine A. Burk...; Andrei A. Purmal; Leonid Brodsky; Mahadeb Pal; Madhi Saranadasa; Dmitry A. Bosykh; Mairead Commane; Olga A. Guryanova; Srabani Pal; Alfiya Safina; Sergey Sviridov; Igor E. Koman; Jean Veith; Anton A. Komar; Andrei V. Gudkov; Katerina V. Gurova
• Keywords: 0301 basic medicine; Cell Death; Transcription, Genetic; Carbazoles; High Mobility Group Proteins; NF-kappa B; Antineoplastic Agents; Models, Biological; Chromatin; 3. Good health; DNA-Binding Proteins; Mice; 03 medical and health sciences; Cell Line, Tumor; Animals; Humans; Cisplatin; Transcriptional Elongation Factors; Tumor Suppressor Protein p53; Casein Kinase II; Cell Proliferation; DNA Damage; Protein Binding

The quinacrine-related compounds curaxins target multiple procancer pathways through FACT complex.