Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

• DOI: 10.1126/scitranslmed.3003316
• Publication Date: 2012-01-26T06:31:26Z
• Authors: Ryohei Katayama; Alice T. Shaw; Tahsin M. Khan; Mari Mino-Kenudson; Benjamin J. Solomon; Balazs Halmos; Nicholas A. Jessop; John C. Wain; Alan Tien Yeo; Cyril Benes; Lisa Drew; Jamal Carlos Saeh; Katherine Crosby; Lecia V. Sequist; A. John Iafrate; Jeffrey A. Engelman
• Keywords: Receptor Protein-Tyrosine Kinases; Acquired resistance; ALK inhibitor

Multiple mechanisms of crizotinib resistance were identified in lung cancer patients including new secondary ALK mutations and activation receptor tyrosine kinases.