Niacin Lipid Efficacy Is Independent of Both the Niacin Receptor GPR109A and Free Fatty Acid Suppression

• DOI: 10.1126/scitranslmed.3003877
• Publication Date: 2012-08-22T18:45:48Z
• Authors: Brett Lauring; Andrew K. P. Taggart; James R. Tata; Richard Dunbar; Luzelena Caro; Kang Cheng; Jayne Chin; Steven L. Colletti; Josee Cote; Sauzanne Khalilieh; Jiajun Liu; Wen-Lin Luo; Alexandra A. MacLean; Laurence B. Peterson; Adam B. Polis; Waheeda Sirah; Tsuei-Ju Wu; Xuan Liu; Lan Jin; Kenneth Wu; P. Douglas Boatman; Graeme Semple; Dominic P. Behan; Daniel T. Connolly; Eseng Lai; John A. Wagner; Samuel D. Wright; Cynthia Cuffie; Yale B. Mitchel; Daniel J. Rader; John F. Paolini; M. Gerard Waters; Andrew Plump
• Keywords: Niacin

GPR109A is not the target mediating niacin’s lipid efficacy and free fatty acid hypothesis does explain mechanism of action.