Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice

• DOI: 10.1126/scitranslmed.3003967
• Publication Date: 2012-07-04T23:09:24Z
• Authors: Lukas C. Heukamp; Theresa Thor; Alexander Schramm; Katleen De Preter; Candy Kumps; Bram De Wilde; Andrea Odersky; Martin Peifer; Sven Lindner; Annika Spruessel; Filip Pattyn; Pieter Mestdagh; Björn Menten; Steffi Kuhfittig-...; Annette Künkele; Katharina König; Lydia Meder; Sampurna Chatterjee; Roland T. Ullrich; Stefanie Schulte; Jo Vandesompele; Frank Speleman; Reinhard Büttner; Angelika Eggert; Johannes H. Schulte
• Keywords: ALK inhibitor

ALK inhibitors induce complete tumor regression in a mouse model of ALK-driven neuroblastoma.