Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABABReceptors with Arbaclofen

• DOI: 10.1126/scitranslmed.3004218
• Publication Date: 2012-09-19T18:16:15Z
• Authors: Christina Henderson; Lasani Wijetunge; Mika Nakamoto Kin...; Matthew Shumway; Rebecca S. Hammond; Friso R. Postma; Christopher Brynczka; Roger Rush; Alexia Thomas; Richard Paylor; Stephen T. Warren; Peter W. Vanderklish; Peter C. Kind; Randall L. Carpenter; Mark F. Bear; Aileen M. Healy
• Keywords: FMR1; Fragile X Syndrome; Knockout mouse

Pharmacological activation of the GABA B receptor with arbaclofen in a mouse model fragile X syndrome corrects neuronal defects associated disease.