Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling

• DOI: 10.1126/scitranslmed.3004330
• Publication Date: 2012-10-24T18:30:03Z
• Authors: Yinyin Yuan; Henrik Failmezger; Oscar M. Rueda; H. Raza Ali; Stefan Gräf; Suet-Feung Chin; Roland F. Schwarz; Christina Curtis; Mark J. Dunning; Helen Bardwell; Nicola Johnson; Sarah Doyle; Gulisa Turashvili; Elena Provenzano; Sam Aparicio; Carlos Caldas; Florian Markowetz
• Keywords: 0301 basic medicine; Gene Expression Profiling; Gene Dosage; Breast Neoplasms; Genomics; Prognosis; Survival Analysis; 3. Good health; Gene Expression Regulation, Neoplastic; Automation; 03 medical and health sciences; Lymphocytes, Tumor-Infiltrating; Receptors, Estrogen; Image Processing, Computer-Assisted; Humans; Female; Stromal Cells

Image analysis of breast cancer tissue improves and complements genomic data to predict patient survival.