Angiotensin-Converting Enzyme–Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4–Deficient Mice

• DOI: 10.1126/scitranslmed.3005025
• Publication Date: 2013-05-01T18:34:17Z
• Authors: Jianbin Huang; Yoshito Yamashiro; Christina L. Papke; Yuichi Ikeda; Yanling Lin; Miteshkumar Patel; Tadashi Inagami; Victoria P. Le; Jessica E. Wagenseil; Hiromi Yanagisawa
• Keywords: Male; Mice, Knockout; 0301 basic medicine; Extracellular Matrix Proteins; Captopril; Angiotensin II; Myocytes, Smooth Muscle; Blood Pressure; Cell Differentiation; Peptidyl-Dipeptidase A; Losartan; Muscle, Smooth, Vascular; Aortic Aneurysm; Biomechanical Phenomena; 3. Good health; Mice; 03 medical and health sciences; Phenotype; Animals; Extracellular Signal-Regulated MAP Kinases; Aorta; Biomarkers; Gene Deletion

Up-regulation of angiotensin-converting enzyme in the aortic wall causes aneurysms in fibulin-4–deficient mice, which can be prevented by losartan or captopril.