Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo

• DOI: 10.1126/scitranslmed.3005127
• Publication Date: 2013-02-27T19:40:13Z
• Authors: Jeffrey A. Mosenson; Andrew Zloza; John D. Nieland; Elizabeth Garrett...; Jonathan M. Eby; Erica J. Huelsmann; Previn Kumar; Cecele J. Denman; Andrew T. Lacek; Frederick J. Kohl...; Ahmad Alamiri; Tasha Hughes; Steven D. Bines; Howard L. Kaufman; Andreas Overbeck; Shikhar Mehrotra; Claudia Hernandez; Michael I. Nishimura; Jose A. Guevara-P...; I. Caroline Le Poole
• Keywords: Hypopigmentation; Inflammation; 0301 basic medicine; Transcription, Genetic; T-Lymphocytes; Antigen-Presenting Cells; Autoimmunity; Dendritic Cells; Genetic Therapy; Lymphocyte Activation; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Phenotype; Disease Progression; Animals; Humans; HSP70 Heat-Shock Proteins; Mutant Proteins; Antigens; Peptides; Skin

Vitiligo can be reversed through immune targeting with mutant heat shock protein 70.