Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells

• DOI: 10.1126/scitranslmed.3005616
• Publication Date: 2013-04-03T21:11:45Z
• Authors: Emre Ozkumur; Ajay M. Shah; Jordan C. Ciciliano; Benjamin L. Emmink; David T. Miyamoto; Elena Brachtel; Min Yu; Pin-i Chen; Bailey Morgan; Julie Trautwein; Anya Kimura; Sudarshana Sengupta; Shannon L. Stott; Nezihi Murat Kara...; Thomas A. Barber; John R. Walsh; Kyle Smith; Philipp S. Spuhler; James P. Sullivan; Richard J. Lee; David T. Ting; Xi Luo; Alice T. Shaw; Aditya Bardia; Lecia V. Sequist; David N. Louis; Shyamala Maheswaran; Ravi Kapur; Daniel A. Haber; Mehmet Toner
• Keywords: Male; Antigens, Neoplasm; Cell Line, Tumor; Magnetic Phenomena; Microfluidics; Humans; Female; Cell Separation; RNA, Neoplasm; Neoplastic Cells, Circulating; Cell Shape; Cell Size; 3. Good health

A multistage microfluidic chip is capable of sorting rare EpCAM + and EpCAM − CTCs from cancer patients’ whole blood.