Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

• DOI: 10.1126/scitranslmed.3007000
• Publication Date: 2013-11-20T19:56:24Z
• Authors: Eloise Hudry; Jonathan Dashkoff; Alysson D. Roe; Shuko Takeda; Robert M. Koffie; Tadafumi Hashimoto; Maria Scheel; Tara Spires-Jones; Michal Arbel-Ornath; Rebecca Betensky; Beverly L. Davidson; Bradley T. Hyman
• Keywords: 0301 basic medicine; Amyloid; Mice; 03 medical and health sciences; Apolipoproteins E; Animals; Brain; Humans; Mice, Transgenic; Transfection; Injections, Intraventricular; 3. Good health

Introduction of different APOE isoforms modulates Aβ peptide aggregation and neurotoxicity after amyloid deposition in mouse brain.