Functional Network Pipeline Reveals Genetic Determinants Associated with in Situ Lymphocyte Proliferation and Survival of Cancer Patients

• DOI: 10.1126/scitranslmed.3007240
• Publication Date: 2014-03-19T18:49:17Z
• Authors: Bernhard Mlecnik; Gabriela Bindea; Helen K. Angell; Maria Stella Sasso; Anna C. Obenauf; Tessa Fredriksen; Lucie Lafontaine; Amelie M. Bilocq; Amos Kirilovsky; Marie Tosolini; Maximilian Waldner; Anne Berger; Wolf Herman Fridman; Arash Rafii; Viia Valge-Archer; Franck Pagès; Michael R. Speicher; Jérôme Galon
• Keywords: Survival Rate; 0303 health sciences; 03 medical and health sciences; Neoplasms; Tumor Microenvironment; Cytokines; Humans; Lymphocytes; Neoplasm Recurrence, Local; Cell Proliferation; 3. Good health

Genomic alterations result in changes of immune cell densities within the tumor.