Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear

• DOI: 10.1126/scitranslmed.3008177
• Publication Date: 2014-04-24T00:11:20Z
• Authors: Jeremy L. Pinyon; Sherif F. Tadros; Kristina E. Froud; Ann C. Y. Wong; Isabella T. Tompson; Edward N. Crawford; Myungseo Ko; Renée Morris; Matthias Klugmann; Gary D. Housley
• Keywords: Bionics; 0301 basic medicine; Brain-Derived Neurotrophic Factor; Guinea Pigs; Gene Transfer Techniques; Ear; Genetic Therapy; Deafness; Transfection; Nerve Regeneration; Mesoderm; Disease Models, Animal; 03 medical and health sciences; Cochlear Implants; Electroporation; Neurites; Animals; Electrodes

Neurotrophin gene delivery, achieved by “close-field” electroporation of mesenchymal cells adjacent to the cochlear implant, improved hearing in deafened guinea pigs.