Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates

• DOI: 10.1126/scitranslmed.aaa3601
• Publication Date: 2015-05-28T11:10:19Z
• Authors: Alexis Courbet; Drew Endy; Eric Renard; Franck Molina; Jérôme Bonnet
• Keywords: Blood Glucose; 0301 basic medicine; Bacteria; Logic; [SDV]Life Sciences [q-bio]; Signal Processing, Computer-Assisted; Biosensing Techniques; 3. Good health; 03 medical and health sciences; Gene Expression Regulation; Glycosuria; Diabetes Mellitus; Humans; Biomarkers

With the use of digital genetic amplifiers and logic gates, prototype whole-cell biosensors can be engineered to detect diagnostic biomarkers in complex human clinical samples.