Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

• DOI: 10.1126/scitranslmed.aaa4097
• Publication Date: 2015-05-20T18:20:10Z
• Authors: Sander van den Dr...; Joni Macdonald; Richard A. Anderson; Zoe C. Johnston; Tarini Chetty; Lee B. Smith; Chris McKinnell; Afshan Dean; Natalie Z. Homer; Anne Jorgensen; Maria E. Camacho-...; Richard M. Sharpe; Rod T. Mitchell
• Keywords: Male; Dose-Response Relationship, Drug; Graft Survival; Down-Regulation; Seminal Vesicles; Steroid 17-alpha-Hydroxylase; Organ Size; Risk Assessment; Rats; 3. Good health; Mice; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Testis; Animals; Heterografts; Humans; Female; Testosterone; Cholesterol Side-Chain Cleavage Enzyme; Orchiectomy; Acetaminophen

Prolonged exposure to therapeutic doses of acetaminophen reduces testosterone production by human fetal testis xenografts in mice.