Therapeutic targeting of casein kinase 1δ in breast cancer

• DOI: 10.1126/scitranslmed.aac8773
• Publication Date: 2015-12-16T19:23:26Z
• Authors: Laura H. Rosenberg; Marie Lafitte; Victor Quereda; Wayne Grant; Weimin Chen; Mathieu Bibian; Yoshihiko Noguchi; Mohammad Fallahi; Chunying Yang; Jenny C. Chang; William R. Roush; John L. Cleveland; Derek R. Duckett
• Keywords: 0301 basic medicine; Dose-Response Relationship, Drug; Computational Biology; Mice, Nude; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Mice, SCID; Gene Expression Regulation, Enzymologic; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Purines; Casein Kinase Idelta; Drug Design; Databases, Genetic; MCF-7 Cells; Animals; Humans; Female; Molecular Targeted Therapy; Protein Kinase Inhibitors; Cell Proliferation

Casein kinase 1δ promotes breast tumorigenesis by activation of β-catenin and can be targeted in some cancers.