Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis

• DOI: 10.1126/scitranslmed.aad6712
• Publication Date: 2016-11-30T19:10:58Z
• Authors: Tobias Petzold; Manuela Thienel; Ildiko Konrad; Irene Schubert; Ron Regenauer; Boj Hoppe; Michael Lorenz; Annekathrin Eckart; Sue Chandraratne; Carsten Lennerz; Christof Kolb; Daniel Braun; Janina Jamasbi; Richard Brandl; Siegmund Braun; Wolfgang Siess; Christian Schulz; Steffen Massberg
• Keywords: Platelet adhesion; Platelet adhesiveness

Blood treated with an oral thrombin inhibitor demonstrates enhanced thrombus formation under flow conditions in humans and rodents.