Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase

• DOI: 10.1126/scitranslmed.aad6833
• Publication Date: 2016-02-11T12:55:09Z
• Authors: Rachael Jarrett; Mariolina Salio; Antonia Lloyd-Lavery; Sumithra Subramaniam; Elvire Bourgeois; Charles Archer; Ka Lun Cheung; Clare Hardman; David Chandler; Maryam Salimi; Danuta Gutowska-O...; Jorge Bernardino ...; Padraic G. Fallon; Helen Jolin; Andrew Mckenzie; Andrzej Dziembowski; Ewa Izabela Podobas; Wojciech Bal; David Johnson; D. Branch Moody; Vincenzo Cerundolo; Graham Ogg
• Keywords: EXPRESSION; Adult; 0301 basic medicine; Adolescent; MATURE DENDRITIC CELLS; T-Lymphocytes; DOWN-REGULATES FILAGGRIN; 610; INNATE LYMPHOID-CELLS; Dermatitis; Cell Separation; Research & Experimental Medicine; Filaggrin Proteins; Atopic; Dermatitis, Atopic; Antigens, CD1; Young Adult; 03 medical and health sciences; Intermediate Filament Proteins; ATOPIC-DERMATITIS; Animals; Humans; Antigens; BRONCHOALVEOLAR LAVAGE FLUID; CLINICAL-EFFICACY; 11 Medical and Health Sciences; Aged; Skin; Science & Technology; CD1; Research & Experimental; Group IV Phospholipases A2; Pyroglyphidae; Cell Biology; COLONY-STIMULATING FACTOR; 06 Biological Sciences; Middle Aged; 3. Good health; Medicine, Research & Experimental; T-CELLS; Medicine; Cytokines; K562 Cells; Life Sciences & Biomedicine; SKIN

Lack of the skin barrier protein filaggrin worsens atopic dermatitis by allergenic activation CD1a-reactive T cells.