Pitx2 modulates a Tbx5 -dependent gene regulatory network to maintain atrial rhythm

• DOI: 10.1126/scitranslmed.aaf4891
• Publication Date: 2016-08-31T18:13:46Z
• Authors: Rangarajan D. Nad...; Michael T. Broman; Bastiaan Boukens; Stefan R. Mazurek; Xinan Yang; Malou van den Boo...; Jenna Bekeny; Margaret Gadek; Tarsha Ward; Min Zhang; Yun Qiao; James F. Martin; Christine E. Seidman; Jon Seidman; Vincent Christoffels; Igor R. Efimov; Elizabeth M. McNally; Christopher R. Weber; Ivan P. Moskowitz
• Keywords: PITX2; Gene regulatory network

A mouse model reveals how seven atrial fibrillation–related risk genes form a network to control heartbeat.