Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo

• DOI: 10.1126/scitranslmed.aag1424
• Publication Date: 2016-10-05T18:14:18Z
• Authors: David C. Adams; Lida P. Hariri; Alyssa J. Miller; Yan Wang; Josalyn L. Cho; Martin Villiger; Jasmin A. Holz; Margit V. Szabari; Daniel L. Hamilos; R. Scott Harris; Jason W. Griffith; Brett E. Bouma; Andrew D. Luster; Benjamin D. Medoff; Melissa J. Suter
• Keywords: 0301 basic medicine; Microscopy; Birefringence; Muscle Relaxation; Respiratory System; Sus scrofa; Muscle, Smooth; Asthma; 03 medical and health sciences; Cartilage; Dogs; Imaging, Three-Dimensional; Case-Control Studies; Animals; Humans; Tomography, Optical Coherence; Muscle Contraction

A birefringence microscopy technique provides structural and functional information about airway smooth muscle in healthy and mild asthmatic subjects.