Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma

• DOI: 10.1126/scitranslmed.aag2196
• Publication Date: 2017-01-18T19:15:40Z
• Authors: Khun Visith Keu; Timothy H. Witney; Shahriar Yaghoubi; Jarrett Rosenberg; Anita Kurien; Rachel Magnusson; John Williams; Frezghi Habte; Jamie R. Wagner; Stephen Forman; Christine Brown; Martin Allen-Auer...; Johannes Czernin; Winson Tang; Michael C. Jensen; Behnam Badie; Sanjiv S. Gambhir
• Keywords: Male; Cytotoxic; T-Lymphocytes; Receptors, Antigen, T-Cell; 610; Gene Expression; Bioengineering; Medical and Health Sciences; Thymidine Kinase; Vaccine Related; 03 medical and health sciences; Rare Diseases; 0302 clinical medicine; Genes, Reporter; Receptors; Genetics; Humans; Prospective Studies; Reporter; Cancer; Aged; Interleukin-13; 5.2 Cellular and gene therapies; Brain Neoplasms; Gene Therapy; Genetic Therapy; Glioma; Biological Sciences; Middle Aged; T-Cell; Brain Disorders; 3. Good health; Brain Cancer; Orphan Drug; Neoplasm Recurrence; Genes; Local; Antigen; Positron-Emission Tomography; Biomedical Imaging; Immunization; Female; Immunotherapy; Development of treatments and therapeutic interventions; Neoplasm Recurrence, Local; Biotechnology; T-Lymphocytes, Cytotoxic

PET gene reporter imaging can be used to monitor the trafficking of therapeutic cytotoxic T cells in glioma patients.