Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal

• DOI: 10.1126/scitranslmed.aah4661
• Publication Date: 2016-11-02T18:15:50Z
• Authors: Chandni V. Jain; Leena Kadam; Marie van Dijk; Hamid-Reza Kohan-...; Brian A. Kilburn; Craig Hartman; Vicki Mazzorana; Allerdien Visser; Michael Hertz; Alan D. Bolnick; Rani Fritz; D. Randall Armant; Sascha Drewlo
• Keywords: Genotype; Placenta; DNA Mutational Analysis; High-Throughput Nucleotide Sequencing; Gestational Age; Prenatal Care; Polymorphism, Single Nucleotide; Trophoblasts; 3. Good health; Pregnancy Trimester, First; 03 medical and health sciences; Fetus; 0302 clinical medicine; Haplotypes; Pregnancy; Prenatal Diagnosis; Mutation; Humans; Female; Cell-Free Nucleic Acids; Microsatellite Repeats

Fetal trophoblast cells obtained noninvasively early in gestation provided fetal DNA for comprehensive targeted sequencing across the genome.