Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage

• DOI: 10.1126/scitranslmed.aai8030
• Publication Date: 2017-01-18T19:15:40Z
• Authors: Raquel Lima e Silva; Yogita Kanan; Adam C. Mirando; Jayoung Kim; Ron B. Shmueli; Valeria E. Lorenc; Seth D. Fortmann; Jason Sciamanna; Niranjan B. Pandey; Jordan J. Green; Aleksander S. Popel; Peter A. Campochiaro
• Keywords: Collagen Type IV; Male; 0301 basic medicine; Diabetic Retinopathy; Angiogenesis Inhibitors; Mice, Transgenic; 3T3 Cells; Protein-Tyrosine Kinases; Integrin alphaVbeta3; Ligands; Choroidal Neovascularization; Macular Edema; 3. Good health; Mice, Inbred C57BL; Macular Degeneration; Mice; 03 medical and health sciences; Microscopy, Fluorescence; Animals; Humans; Female; Phosphorylation; Peptides

An integrin-binding peptide derived from collagen IV prevents ligand-induced activation of multiple tyrosine kinase receptors and strongly suppresses ocular neovascularization vascular leakage.