The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway

• DOI: 10.1126/scitranslmed.aal3322
• Publication Date: 2017-07-19T20:05:20Z
• Authors: Zhenke Wen; Yi Shen; Gerald Berry; Farhad Shahram; Yinyin Li; Ryu Watanabe; Yaping Joyce Liao; Jörg J. Goronzy; Cornelia M. Weyand
• Keywords: Adventitia

Microvascular endothelial cells in the arterial adventitia have immunoregulatory function and build an instructive tissue niche for induction of pathogenic T giant cell arteritis.