KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

• DOI: 10.1126/scitranslmed.aar2718
• Publication Date: 2018-08-15T18:05:25Z
• Authors: Euan S. Polson; Verena B. Kuchler; Christopher Abbosh; Edith M. Ross; Ryan K. Mathew; Hester A. Beard; Bárbara da Silva; Andrew N. Holding; Stephane Ballereau; Eulashini Chuntha...; Jennifer Williams; Hollie B.S. Griff...; Hao Shao; Anjana Patel; Adam J. Davies; Alastair Droop; Paul Chumas; Susan C. Short; Mihaela Lorger; Jason E. Gestwicki; Lee D. Roberts; Robin S. Bon; Simon J. Allison; Shoutian Zhu; Florian Markowetz; Heiko Wurdak
• Keywords: 0303 health sciences; Brain Neoplasms; Citric Acid Cycle; Apoptosis; Chaperonin 60; Survival Analysis; Mitochondria; 3. Good health; Mitochondrial Proteins; Disease Models, Animal; Thiazoles; 03 medical and health sciences; Stress, Physiological; Cell Line, Tumor; Autophagy; Animals; Humans; Neoplasm Invasiveness; Energy Metabolism; Glioblastoma; Glycolysis; Metabolic Networks and Pathways; Cell Proliferation

Modulation of energy metabolism with the small-molecule KHS101 promoted tumor-selective death of human glioblastoma cells and reduced tumor growth in mice.