LRRK2 activation in idiopathic Parkinson’s disease

• DOI: 10.1126/scitranslmed.aar5429
• Publication Date: 2018-07-25T18:10:12Z
• Authors: Roberto Di Maio; Eric K. Hoffman; Emily M. Rocha; Matthew T. Keeney; Laurie H. Sanders; Briana R. De Miranda; Alevtina Zharikov; Amber Van Laar; Antonia F. Stepan; Thomas A. Lanz; Julia K. Kofler; Edward A. Burton; Dario R. Alessi; Teresa G. Hastings; J. Timothy Greena...
• Keywords: LRRK2

Wild-type LRRK2 is activated in nigrostriatal dopamine neurons idiopathic Parkinson’s disease and plays a pathogenic role this neurodegenerative disorder.