Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition

• DOI: 10.1126/scitranslmed.aau8465
• Publication Date: 2019-05-15T23:45:11Z
• Authors: William P. Esler; Gregory J. Tesz; Marc K. Hellerstein; Carine Beysen; Raja Sivamani; Scott M. Turner; Steven M. Watkins; Paul A. Amor; Santos Carvajal-G...; Frank J. Geoly; Kathleen E. Biddle; Julie J. Purkal; Mark Fitch; Clare Buckeridge; Annette M. Silvia; David A. Griffith; Matthew Gorgoglione; Lauren Hassoun; Suzana S. Bosanac; Nicholas B. Vera; Timothy P. Rolph; Jeffrey A. Pfeffe...; Gabriele E. Sonne...
• Keywords: Adult; Male; 0301 basic medicine; Adolescent; Swine; Lipogenesis; Middle Aged; 3. Good health; Malonyl Coenzyme A; Sebum; Sebaceous Glands; 03 medical and health sciences; Cricetinae; Acne Vulgaris; Animals; Humans; Swine, Miniature; Female; Enzyme Inhibitors; Rats, Wistar; Cells, Cultured; Triglycerides; Acetyl-CoA Carboxylase

De novo lipogenesis is essential for human sebum production, and increased lipogenic flux accounts for excessive sebum production in acne vulgaris.