Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates

• DOI: 10.1126/scitranslmed.aav7325
• Publication Date: 2019-05-22T23:09:19Z
• Authors: Michela Milani; Andrea Annoni; Federica Moalli; Tongyao Liu; Daniela Cesana; Andrea Calabria; Sara Bartolaccini; Mauro Biffi; Fabio Russo; Ilaria Visigalli; Andrea Raimondi; Susannah Patarroy...; Douglas Drager; Patrizia Cristofori; Eduard Ayuso; Eugenio Montini; Robert Peters; Matteo Iannacone; Alessio Cantore; Luigi Naldini
• Keywords: 0301 basic medicine; Phagocytes; 0303 health sciences; Kupffer Cells; [SDV]Life Sciences [q-bio]; Genetic Vectors; Lentivirus; Gene Transfer Techniques; CD47 Antigen; Genetic Therapy; Immunity, Innate; 3. Good health; [SDV] Life Sciences [q-bio]; Mice, Inbred C57BL; 03 medical and health sciences; Liver; Phagocytosis; Mice, Inbred NOD; Hepatocytes; Immune Tolerance; Animals; Humans; Macaca; Tissue Distribution

Lentiviral vectors with high surface content of CD47 improved gene transfer efficiency to hepatocytes in nonhuman primates.