Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis

• DOI: 10.1126/scitranslmed.aaw0790
• Publication Date: 2019-06-19T23:14:21Z
• Authors: Joseph Yusup Shin; James Daniel Beckett; Rustam Bagirzadeh; Tyler J. Creamer; Ami A. Shah; Zsuzsanna McMahan; Julie J. Paik; Margaret M. Sampedro; Elena G. MacFarlane; Michael A. Beer; Daniel Warren; Fredrick M. Wigley; Harry C. Dietz
• Keywords: 0301 basic medicine; Scleroderma, Systemic; Tumor Necrosis Factor-alpha; NF-kappa B; Cell Cycle Proteins; Fibroblasts; Fibrosis; Epigenesis, Genetic; Transforming Growth Factor beta2; 03 medical and health sciences; Transforming Growth Factor beta; Humans; Histone Acetyltransferases; Skin; Transcription Factors

NF-κB and BRD4 epigenetically activate a TGFB2 enhancer to lock sclerotic patient fibroblasts into a profibrotic synthetic state.