BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis

• DOI: 10.1126/scitranslmed.aax4517
• Publication Date: 2020-05-06T23:21:41Z
• Authors: Byron Brook; Danny J. Harbeson; Casey P. Shannon; Bing Cai; Daniel He; Rym Ben-Othman; Freddy Francis; Joe Huang; Natallia Varankovich; Aaron Liu; Winnie Bao; Morten Bjerregaar...; Frederik Schaltz-...; Lilica Sanca; Christian N. Golding; Kristina Lindberg...; Ofer Levy; Beate Kampmann; ; Rusung Tan; Adrian Charles; James L. Wynn; Frank Shann; Peter Aaby; Christine S. Benn; Scott J. Tebbutt; Tobias R. Kollmann; Nelly Amenyogbe; Amy H. Lee; Tue B. Bennike; Joann Diray-Arce; Olubukola Idoko; William S. Pomat; Simon van Haren; Momoudou Cox; Alansana Darboe; Reza Falsafi; Samuel H. Hinshaw; Jorjoh Ndure; Jainaba Njie-Jobe; Matthew A. Petten...; Arnaud Marchant; Peter C. Richmond; Rebecca Ford; Gerard Saleu; Geraldine Masiria; John Paul Matlam; Wendy Kirarock; Elishia Roberts; Mehrnoush Malek; Guzman Sanchez-Sc...; Amrit Singh; Asimenia Angelidou; Kinga K. Smolen; Ryan R. Brinkman; Al Ozonoff; Robert E.W. Hancock; Anita H.J. van de...; Hanno Steen; Diana Vo; Ken Kraft; Kerry McEnaney; Sofia Vignolo
• Keywords: Vaccination; Infant, Newborn; 610; Hematopoiesis; 3. Good health; 618; 03 medical and health sciences; 0302 clinical medicine; Sepsis; Granulocyte Colony-Stimulating Factor; Humans; Neonatal Sepsis

Neonatal administration of BCG vaccine rapidly increases neutrophil production to reduce mortality from sepsis.