Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin

• DOI: 10.1126/scitranslmed.aaz9705
• Publication Date: 2021-08-25T19:15:16Z
• Authors: Rebecca Herzog; Juan Manuel Sacnun; Guadalupe Gonzále...; Maria Bartosova; Katarzyna Bialas; Anja Wagner; Markus Unterwurza...; Isabel J. Sobieszek; Lisa Daniel-Fischer; Krisztina Rusai; Lucía Pascual-Antón; Klaus Kaczirek; Andreas Vychytil; Claus Peter Schmitt; Manuel López-Cabrera; Seth L. Alper; Christoph Aufricht; Klaus Kratochwill
• Keywords: Proteomics; Vascular Endothelial Growth Factor A; 0303 health sciences; Epithelial Cells; Peritoneal Fibrosis; Lithium; Crystallins; 3. Good health; Mice; 03 medical and health sciences; Animals; Humans; Peritoneum; Child

Lithium added to peritoneal dialysis fluid protects mesothelial cells and attenuates peritoneal fibrosis and angiogenesis by reducing αB-crystallin.