Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

• DOI: 10.1126/scitranslmed.abb0203
• Publication Date: 2021-05-19T19:11:43Z
• Authors: Katie J. Mylonas; Eoin D. O’Sullivan; Duncan Humphries; David P. Baird; Marie-Helena Doch...; Sarah A. Neely; Paul J. Krimpenfort; Anette Melk; Roland Schmitt; Sofia Ferreira-Go...; Stuart J. Forbes; Jeremy Hughes; David A. Ferenbach
• Keywords: Senescence; Renal Injury

Senescent renal epithelia promote fibrosis and functional loss after injury, whereas depletion improves regeneration in aged or irradiated kidneys.