Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice

• DOI: 10.1126/scitranslmed.abc7275
• Publication Date: 2021-06-30T19:12:13Z
• Authors: Xiaoguang Fang; Zhi Huang; Kui Zhai; Qian Huang; Weiwei Tao; Leo Kim; Qiulian Wu; Alexandru Almasan; Jennifer S. Yu; Xiaoxia Li; George R. Stark; Jeremy N. Rich; Shideng Bao
• Keywords: 2. Zero hunger; 0301 basic medicine; 0303 health sciences; Brain Neoplasms; SOXB1 Transcription Factors; Cell Differentiation; DNA-Activated Protein Kinase; Glioma; 3. Good health; DNA-Binding Proteins; Mice; 03 medical and health sciences; Cell Line, Tumor; Neoplastic Stem Cells; Animals; Glioblastoma

Targeting DNA-PK induces glioma stem cell differentiation by destabilizing SOX2 to inhibit tumor growth in mouse glioblastoma models.