Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset

• DOI: 10.1126/scitranslmed.abd9898
• Publication Date: 2021-05-05T19:13:25Z
• Authors: Ina A. Stelzer; Mohammad S. Ghaemi; Xiaoyuan Han; Kazuo Ando; Julien J. Hédou; Dorien Feyaerts; Laura S. Peterson; Kristen K. Rumer; Eileen S. Tsai; Edward A. Ganio; Dyani K. Gaudillière; Amy S. Tsai; Benjamin Choisy; Lea P. Gaigne; Franck Verdonk; Danielle Jacobsen; Sonia Gavasso; Gavin M. Traber; Mathew Ellenberger; Natalie Stanley; Martin Becker; Anthony Culos; Ramin Fallahzadeh; Ronald J. Wong; Gary L. Darmstadt; Maurice L. Druzin; Virginia D. Winn; Ronald S. Gibbs; Xuefeng B. Ling; Karl Sylvester; Brendan Carvalho; Michael P. Snyder; Gary M. Shaw; David K. Stevenson; Kévin Contrepois; Martin S. Angst; Nima Aghaeepour; Brice Gaudillière
• Keywords: 0301 basic medicine; Proteome; Maternal Health; Medical biotechnology; 610; Reproductive health and childbirth; Medical and Health Sciences; 618; 03 medical and health sciences; Pregnancy; 2.1 Biological and endogenous factors; Humans; Longitudinal Studies; Pediatric; 0303 health sciences; Biomedical and Clinical Sciences; Contraception/Reproduction; Biological Sciences; 4.1 Discovery and preclinical testing of markers and technologies; 3. Good health; Good Health and Well Being; Reproductive Medicine; Metabolome; Women's Health; Labor Onset; Female; Biomedical engineering; Biomarkers; Biotechnology

Peripheral blood dynamics in the 100 days before delivery reveal a transition from pregnancy maintenance to prelabor biology.