A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice

• DOI: 10.1126/scitranslmed.abf1383
• Publication Date: 2021-07-21T19:10:13Z
• Authors: Matthew W. Boudreau; Darjan Duraki; Lawrence Wang; Chengjian Mao; Ji Eun Kim; Madeline A. Henn; Bingtao Tang; Sean W. Fanning; Jeffrey Kiefer; Theodore M. Tarasow; Elizabeth M. Bruc...; Ramon Moreno; Spyro Mousses; Geoffrey L. Greene; Edward J. Roy; Ben Ho Park; Timothy M. Fan; Erik R. Nelson; Paul J. Hergenrother; David J. Shapiro
• Keywords: Estrogen Receptor alpha; Breast Neoplasms; Cell Line; Rats; 3. Good health; Mice; 03 medical and health sciences; Dogs; 0302 clinical medicine; Cell Line, Tumor; Unfolded Protein Response; Animals; Humans; Female; Neoplasm Recurrence, Local

Activation of the unfolded protein response induces regression of estrogen receptor α–positive breast cancer xenografts in mice.