An AAV gene therapy computes over multiple cellular inputs to enable precise targeting of multifocal hepatocellular carcinoma in mice

• DOI: 10.1126/scitranslmed.abh4456
• Publication Date: 2021-12-15T18:58:09Z
• Authors: Bartolomeo Angelici; Linling Shen; Joerg Schreiber; Anthony Abraham; Yaakov Benenson
• Keywords: Thymidine kinase

Gene therapy that regulates an antitumor gene via a multi-input biomolecular logic module treats multifocal tumors in mouse model of liver cancer.