Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria

• DOI: 10.1126/scitranslmed.abn5993
• Publication Date: 2023-02-08T18:59:09Z
• Authors: Dennis O. Odera; James Tuju; Kennedy Mwai; Irene N. Nkumama; Kristin Fürle; Timothy Chege; Rinter Kimathi; Stefan Diehl; Fauzia K. Musasia; Micha Rosenkranz; Patricia Njuguna; Mainga Hamaluba; Melissa C. Kapulu; Roland Frank; ; Faith H. A. Osier; Abdirahman I. Abdi; Primus Che Chi; Zaydah de Laurent; Irene Jao; Dorcas Kamuya; Gathoni Kamuyu; Johnstone Makale; Linda Murungi; Jennifer Musyoki; Michelle Muthui; Jedidah Mwacharo; Silvia Kariuki; Daniel Mwanga; Joyce Mwongeli; Francis Ndungu; Maureen Njue; George Nyangweso; Domitila Kimani; Joyce M. Ngoi; Janet Musembi; Omar Ngoto; Edward Otieno; Michael Ooko; Jimmy Shangala; Juliana Wambua; Khadija Said Moha...; Donwilliams Omuoyo; Moses Mosobo; Nelson Kibinge; Sam Kinyanjui; Philip Bejon; Brett Lowe; Kevin Marsh; Vicki Marsh; Yonas Abebe; Peter F. Billingsley; Betty Kim Lee Sim; Stephen L. Hoffman; Eric R. James; Thomas L. Richie; Agnes Audi; Fredrick Olewe; James Oloo; John Ongecha; Martin O. Ongas; Nelly Koskei; Peter C. Bull; Susanne H. Hodgson; Cheryl Kivisi; Mallika Imwong; Sean C. Murphy; Bernhards Ogutu; Joel Tarning; Markus Winterberg; Thomas N. Williams
• Keywords: Adult; 0301 basic medicine; Merozoites; Plasmodium falciparum; Antibodies, Protozoan; Antigens, Protozoan; Article; Malaria; Cohort Studies; Killer Cells, Natural; 03 medical and health sciences; Animals; Humans; Malaria, Falciparum; Child

Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found NK degranulate and release IFN-γ upon stimulation with antibody-opsonized