TSPAN8 + myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer

• DOI: 10.1126/scitranslmed.adj5705
• Publication Date: 2024-04-03T17:58:22Z
• Authors: Guangjian Fan; Bo Yu; Lei Tang; Rongxuan Zhu; Jianhua Chen; Ying Zhu; He Huang; Liying Zhou; Jun Liu; Wei Wang; Zhonghua Tao; Fengchun Zhang; Siwei Yu; Xiaoqing Lu; Yuan Cao; Shaoqian Du; Huihui Li; Junjian Li; Jian Zhang; He Ren; Olivier Gires; Haikun Liu; Xin Wang; Jun Qin; Hongxia Wang
• Keywords: Cancer-Associated Fibroblasts; Tumor progression; Senescence; SIRT6

Cancer-associated fibroblasts (CAFs) are abundant stromal cells in the tumor microenvironment that promote cancer progression and relapse. However, heterogeneity regulatory roles of CAFs underlying chemoresistance remain largely unclear. Here, we performed a single-cell analysis using high-dimensional flow cytometry identified distinct senescence-like tetraspanin-8 (TSPAN8)