The Quorum-Sensing Inhibitor Furanone C-30 Rapidly Loses Its Tobramycin-Potentiating Activity against Pseudomonas aeruginosa Biofilms during Experimental Evolution

0301 basic medicine 03 medical and health sciences Biofilms Pseudomonas aeruginosa Tobramycin Quorum Sensing Furans Anti-Bacterial Agents 3. Good health
DOI: 10.1128/aac.00413-21 Publication Date: 2021-04-22T13:42:09Z
ABSTRACT
The use of quorum-sensing inhibitors (QSI) has been proposed as an alternative strategy to combat antibiotic resistance. QSI reduce the virulence of a pathogen without killing it and it is claimed that resistance to such compounds is less likely to develop, although there is a lack of experimental data supporting this hypothesis.
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