The Quorum-Sensing Inhibitor Furanone C-30 Rapidly Loses Its Tobramycin-Potentiating Activity against Pseudomonas aeruginosa Biofilms during Experimental Evolution

• DOI: 10.1128/aac.00413-21
• Publication Date: 2021-04-22T13:42:09Z
• Authors: Mona Bové; Xuerui Bao; Andrea Sass; Aurélie Crabbé; Tom Coenye
• Keywords: 0301 basic medicine; 03 medical and health sciences; Biofilms; Pseudomonas aeruginosa; Tobramycin; Quorum Sensing; Furans; Anti-Bacterial Agents; 3. Good health

The use of quorum-sensing inhibitors (QSI) has been proposed as an alternative strategy to combat antibiotic resistance. QSI reduce the virulence of a pathogen without killing it and it is claimed that resistance to such compounds is less likely to develop, although there is a lack of experimental data supporting this hypothesis.