Origins and Evolution of Methicillin-ResistantStaphylococcus aureusClonal Lineages

• DOI: 10.1128/aac.00521-06
• Publication Date: 2006-09-27T17:13:29Z
• Authors: A. R. Gomes; H. Westh; H. de Lencastre
• Keywords: Phage typing

Most methicillin-resistant Staphylococcus aureus (MRSA) isolates identified among blood collected in Denmark between 1957 and 1970 belonged to either phage group III or the closely related 83A complex had a PSTM antibiotype (resistance penicillin [P], streptomycin [S], tetracycline [T], methicillin [M]). Recently, some of these were shown have same genetic backgrounds as contemporary epidemic MRSA isolates, Danish methicillin-susceptible S. (MSSA) from 1960s with PST proposed been recipients mecA gene those lineages. In this study, we investigated that fully susceptible resistant only order try trace evolutionary trajectory We also studied MSSA other groups investigate if they potential develop into clones. penicillin-resistant sequence type 8 (ST8) ST5, while four ST254. STs 30, 45 25 represented by groups, which included several singletons. Representatives most current major lineages 1960s, suggesting carried traits important for superior epidemicity before acquisition resistance.