Mutations in gyrA and gyrB in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates

• DOI: 10.1128/aac.00527-18
• Publication Date: 2018-06-19T10:22:35Z
• Authors: Su-Young Kim; Byung Woo Jhun; Seong Mi Moon; Sun Hye Shin; Kyeongman Jeon; O Jung Kwon; In Young Yoo; Hee Jae Huh; Chang-Seok Ki; Nam Yong Lee; Sung Jae Shin; Charles L. Daley; Gee Young Suh; Won-Jung Koh
• Keywords: Mycobacterium abscessus; Mycobacterium avium complex

Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates Mycobacterium avium complex (MAC) abscessus (MABC) are limited. In our analysis, we did not find any resistance-associated or 105 MAC MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than contribute to moxifloxacin resistance these organisms.