Role of Lock Therapy for Long-Term Catheter-Related Infections by Multidrug-Resistant Bacteria

• DOI: 10.1128/aac.00569-18
• Publication Date: 2018-07-04T11:49:52Z
• Authors: Maristela P. Freire; Ligia C. Pierrotti; Antonio E. Zerati; Luciana Benites; Joaquim Mauricio ...; Karim Y. Ibrahim; Pedro H. Araujo; Edson Abdala
• Keywords: Central venous catheter

The management of long-term central venous catheter (LTCVC) infections by multidrug-resistant (MDR) bacteria in cancer patient is a challenge. objectives this study were to analyze outcomes patients with LTCVC-associated infection, identify risks for unfavorable outcomes, and determine the impact MDR antibiotic lock therapy (ALT) managing such infections. We evaluated all treated between January 2009 December 2016. Infections reported accordance international guidelines catheter-related outcome measures 30-day mortality treatment failure. analyzed risk factors Cox forward-stepwise regression. identified 296 infections; 212 (71.6%) classified as bloodstream (BSIs). most common agent was Staphylococcus aureus Forty-six (21.7%) due Gram-negative bacteria. ALT used 62 (29.2%) patients, 75.9% success rate. Risk failure initial having high sequential organ assessment (SOFA) score at diagnosis infection being palliative care; introduction start protective factor. after SOFA diagnosis, bacteria, treatment, hematological malignancies, adherence an institutional protocol factors. Despite incidence improves patients.