Bronchopulmonary penetration of isavuconazole in lung transplant recipients

• DOI: 10.1128/aac.00613-23
• Publication Date: 2023-10-03T13:10:53Z
• Authors: Antonio F. Caball...; Ignacio Darnaude-...; Myriam Aguilar-Pérez; Alicia Gomez-Lopez; Aránzazu Sancho-L...; Cristina López Ga...; Gema Díaz Nuevo; Elena Diago-Sempere; Belén Ruiz-Antorán; Cristina Avendaño...; Piedad Ussetti-Gil
• Keywords: Penetration (warfare)

Isavuconazole's (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), 6.31 0.95) at 2 h, 4 24 h respectively. Mean in the epithelial lining fluid were 0.969 0.895), 2.141 1.265), 2.812 0.693) same time points. ISA is a drug with tolerable safety profile that achieves adequate lung.