Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-β-Lactamase Clones (VIM-2, -5, -6, and -11 and the Newly Characterized VIM-18)

• DOI: 10.1128/aac.01011-08
• Publication Date: 2008-12-30T04:54:53Z
• Authors: Mariana Castanheira; Jan M. Bell; John D. Turnidge; Dillip Mathai; Ronald N. Jones
• Keywords: Carbapenem

Among 57 metallo-beta-lactamase (MbetaL)-producing Pseudomonas spp. detected in India during 2006, five bla(VIM) genes were found, including a newly characterized gene. aeruginosa strains clustered 33 ribotypes with clones found multiple hospitals. Several types of bla(VIM-2)-carrying integrons detected. The variant VIM-18 showed 4-amino-acid deletion compared to other VIM variants. In this study, we show that VIM-producing highly prevalent great diversity and MbetaL-carrying integrons.