Candida Bloodstream Infections: Comparison of Species Distributions and Antifungal Resistance Patterns in Community-Onset and Nosocomial Isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009

• DOI: 10.1128/aac.01079-10
• Publication Date: 2010-11-30T09:45:25Z
• Authors: Michael A. Pfaller; Gary J. Moet; Shawn A. Messer; Ronald N. Jones; Mariana Castanheira
• Keywords: Anidulafungin; Posaconazole; Candida parapsilosis; Candida glabrata; Candida krusei; Fungemia

ABSTRACT Community-onset (CO) candidemia, defined as a positive blood culture taken at or within 2 days of hospital admission, represents distinct clinical entity associated with substantial morbidity and mortality. Reference MIC results from the SENTRY Antimicrobial Surveillance Program (2008-2009) were analyzed to compare antifungal resistance patterns species distributions patients CO nosocomial bloodstream infections (BSI) in 79 medical centers. Among 1,354 episodes BSI, 494 (36.5%) classified 860 (63.5%) origin. More than 95% isolates both BSI types contributed by Candida albicans (48.4%), C. glabrata (18.2%), parapsilosis (17.1%), tropicalis (10.6%), krusei (2.0%). was more common (51.0%) (46.9%), whereas BSIs (18.1 2.7%, respectively) (15.4 0.8%, respectively). comparable (18.4 10.5%, 10.6%, episodes. Resistance azoles (fluconazole, posaconazole, voriconazole) echinocandins (anidulafungin, caspofungin, micafungin) uncommon (<5%) using recently established Clinical Laboratory Standards Institute breakpoint criteria. (anidulafungin [3.8%], caspofungin [5.1%], micafungin [3.2%]) (fluconazole [7.7%], posaconazole voriconazole [6.4%]) most prevalent among . candidemia is not appears be increasing worldwide due changing health care practices. Although remains isolates, we demonstrate emergence occurrences expressing monitored classes agents.