Early Bayesian Dose Adjustment of Vancomycin Continuous Infusion in Children in a Randomized Controlled Trial

• DOI: 10.1128/aac.01102-19
• Publication Date: 2019-10-03T11:25:30Z
• Authors: Romain Berthaud; Sihem Benaboud; Déborah Hirt; Mathieu Genuini; Mehdi Oualha; Martin Castelle; Coralie Briand; Solène Artru; Lorenzo Norsa; Olivia Boyer; Frantz Foissac; Naïm Bouazza; Jean-Marc Tréluyer
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Methicillin-resistant staphylococcal infections are a global burden. Area under the concentration-time curve to MIC (AUC/MIC) ratio is the pharmacokinetic (PK) parameter that best predicts vancomycin efficacy. Its therapeutic range is narrow, difficult to achieve because of a wide intersubject variability, especially in children, and is not routinely targeted since the AUC is rarely available.