Colistin Resistance Gene mcr-1 and Its Variant in Escherichia coli Isolates from Chickens in China

• DOI: 10.1128/aac.01204-16
• Publication Date: 2017-02-28T01:40:27Z
• Authors: Yong-Qiang Yang; Yun-Xia Li; Tao Song; Yan-Xian Yang; Wei Jiang; An-Yun Zhang; Xin-Yi Guo; Bi-Hui Liu; Yong-Xiang Wang; Chang-Wei Lei; Rong Xiang; Hong-Ning Wang
• Keywords: MCR-1; Colistin; Enterobacteriaceae Infections; Strain (injury)

The mcr-1 gene was detected in 5.11% (58/1136) of Escherichia coli isolates chicken origin from 13 provinces China. A novel variant, named mcr-1.3, encoding an Ile-to-Val functional variant MCR-1 identified a sequence type 155 (ST155) strain. An mcr-1.3-containing IncI2 plasmid, pHeN867 (60,757 bp), identified. transfer led to 32-fold increase the MIC colistin recipient, exhibiting effect on resistance that similar mcr-1.