Impact of hypoalbuminemia on clinical outcomes among patients with obesity treated with ceftriaxone

• DOI: 10.1128/aac.01663-23
• Publication Date: 2024-02-27T16:42:03Z
• Authors: Kellie Arensman H...; Evan Draper; Kristin C. Cole; Jack Mc Hugh; Christina G. Rivera; Omar Abu Saleh
• Keywords: Hypoalbuminemia

The use of ceftriaxone, a highly protein-bound drug, in the setting hypoalbuminemia may result suboptimal drug exposure. Patients with obesity also exhibit higher absolute clearance. We aimed to evaluate impact on clinical success among hospitalized adults who were treated ceftriaxone. This retrospective review included adult inpatients weight >100 kg or body mass index >40 kg/m