Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne bla KPC Carbapenemase in Enterobacterales in the United Kingdom from 2009 to 2014

• DOI: 10.1128/aac.02244-19
• Publication Date: 2020-04-20T15:03:38Z
• Authors: Nicole Stoesser; Hang T. T. Phan; Anna C. Seale; Zoie Aiken; Stephanie Thomas; Matthew Smith; David Wyllie; Ryan George; Robert Sebra; Amy J. Mathers; Alison Vaughan; Timothy E. A. Peto; Matthew J. Ellington; Katie L. Hopkins; Derrick W. Crook; Alex Orlek; William Welfare; Julie Cawthorne; Cheryl Lenney; Andrew Dodgson; Neil Woodford; A. Sarah Walker; ; Zoie Aiken; Oluwafemi Akinremi; Aiysha Ali; Julie Cawthorne; Paul Cleary; Derrick W. Crook; Valerie Decraene; Andrew Dodgson; Michel Doumith; Matthew J. Ellington; Ryan George; John Grimshaw; Malcolm Guiver; Robert Hill; Katie L. Hopkins; Rachel Jones; Cheryl Lenney; Amy J. Mathers; Ashley McEwan; Ginny Moore; Mark Neilson; Sarah Neilson; Timothy E. A. Peto; Hang T. T. Phan; Mark Regan; Anna C. Seale; Nicole Stoesser; Jay Turner-Gardner; Vicky Watts; A. Sarah Walker; Jimmy Walker; David Wyllie; William Welfare; Neil Woodford
• Keywords: Molecular Epidemiology; Carbapenem

Carbapenem resistance in Enterobacterales is a public health threat. Klebsiella pneumoniae carbapenemase (encoded by alleles of the bla KPC family) one most common transmissible carbapenem mechanisms worldwide. The dissemination historically has been associated with distinct K. lineages (clonal group 258 [CG258]), particular plasmid family (pKpQIL), and composite transposon (Tn 4401 ).