Mycobacterium tuberculosis Is Selectively Killed by Rifampin and Rifapentine in Hypoxia at Neutral pH

• DOI: 10.1128/aac.02296-16
• Publication Date: 2016-12-23T17:28:40Z
• Authors: Angelo Iacobino; Giovanni Piccaro; Federico Giannoni; Alessandro Mustaz...; Lanfranco Fattorini
• Keywords: Rifapentine; Clofazimine; Cycloserine; Rifamycin; Amikacin; Bedaquiline; Capreomycin; Pyrazinamide

The activities of rifampin, rifapentine, bedaquiline, PA-824, clofazimine, nitazoxanide, isoniazid, amikacin, moxifloxacin, niclosamide, thioridazine, and pyrazinamide were tested against nonreplicating (dormant) Mycobacterium tuberculosis H37Rv under conditions hypoxia at pHs 5.8 7.3, mimicking environments cellular granulomas caseous granulomas, respectively. At pH 5.8, several drugs killed dormant bacilli, with the best being rifampin rifapentine. only rifapentine efficiently while all other showed little activity.