Molecular Characterization of Streptococcus agalactiae Isolates Harboring Small erm (T)-Carrying Plasmids

• DOI: 10.1128/aac.03855-14
• Publication Date: 2014-08-19T05:54:44Z
• Authors: Fabrice Compain; Constantin Hays; Gérald Touak; Nicolas Dmytruk; Patrick Trieu-Cuot; Caroline Joubrel; Claire Poyart
• Keywords: 0303 health sciences; Base Sequence; Methyltransferases; Microbial Sensitivity Tests; Sequence Analysis, DNA; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; Anti-Bacterial Agents; Erythromycin; Streptococcus agalactiae; 3. Good health; 03 medical and health sciences; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Streptococcal Infections; [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; Serotyping; Bacterial Capsules; Plasmids

ABSTRACT

Among 1,827 group B Streptococcus (GBS) strains collected between 2006 and 2013 by the French National Reference Center for Streptococci, 490 (26.8%) strains were erythromycin resistant. The erm (T) resistance gene was found in six strains belonging to capsular polysaccharides Ia, III, and V and was carried by the same mobilizable plasmid, which could be efficiently transferred by mobilization to GBS and Enterococcus faecalis recipients, thus promoting a broad dissemination of erm (T).